When I’m at my work or home PC, I’m almost always wearing headphones.
Often, I’ll be listening to fairly repetitive, unobtrusive music (such the Pandora trip-hop station), which I find helps me work on long projects.
But even when I’m not listening to music, I tend to wear my headphones for two other reasons. First, it tends to keep people from interrupting me unless it is something at least semi-important. Second, even without music, wearing headphones somehow seems to keep me pretty focused on my work, strange as that may seem.