If you spend much time on a desktop computer, install and learn the basics of Auto Hotkey (www.autohotkey.com), which lets you create short cuts for almost everything.
I primarily use this to run common programs and to open common file locations. My specific script uses CTRL+ALT to launch nearly everything I need:
CTRL+ALT+a = Acrobat
CTRL+ALT+c = my Computer
CTRL+ALT+d = show Desktop
CTRL+ALT+e = Edge browser (although I now use Chrome)
CTRL+ALT+f = Files (“My Documents”)
CTRL+ALT+g = Dropbox
CTRL+ALT+i = iTunes
CTRL+ALT+o = Outlook
CTRL+ALT+p = PowerPoint
CTRL+ALT+q = main network drive at work
CTRL+ALT+v = Vice Versa (backup program)
CTRL+ALT+w = Word
CTRL+ALT+x = Excel
The shortcuts are easy to remember because of the letter associations. Also, ten of them can be launched with one hand. In particular, I use my left pinky and thumb to hit CTRL and ALT, and then use my left second or third finger to hit a, c, d, e, f, g, q, v, w, or x (which in turn leaves my right hand free to operate the mouse).
One Idea 